Author: Michael Kelley

Little Has Changed since 2011: The Hidden Challenges of Dental Sleep Medicine

The article featured below is not only a great overview of the opportunity that sleep apnea presents to dentistry at large, but also the hurdles that are required to be overcome in order to capitalize on the opportunity. Dr Barry Gassman has been a clinician and an educator in this field since its inception. He is well known for his commitment to evidence based medicine and has a grasp of the literature illustrates his literacy. I have heard Dr Glassman in his role as educator and his passion for the field is without question. I was recently made aware of this article from 2011 and was struck by how timeless it is. Sadly the practice of sleep medicine is still determined largely by the site and discipline that formed the diagnosis. In spite of changes in reimbursement and excellent research indicating increased patient compliance with oral appliances. physicians seem to still adhere to CPAP as the gold standard of care. This article previously appeared in DentalTown magazine May 2011- ed The Hidden Challenges of Dental Sleep Medicine I want to bring some reality to the economics of dental sleep medicine, an area for dentists that is being promoted by many as a new profit center in the dental practice. There is no question that adding this service to your armamentarium has the potential not only to improve the quality of life for many of your patients, but also provide increased income. Along with the ability to increase services and income, dental sleep medicine provides many new challenges to the dentist, which are often ignored or underestimated. The dentist will only be in a position to provide a therapy that could be essential to the patient’s quality of life if the challenges are recognized and conquered. What is Sleep Medicine? Sleep medicine is a relatively new specialty of medicine. In a 2005 article, Shepard, et al. stated “the history of the development of sleep medicine in the United States is relatively short and most of the individuals involved with its development are still living.”1 They go on to state: “Until 1975 sleep medicine was deemed ‘experimental’ and medical insurance companies routinely denied reimbursement claims.” In discussing the development of the specialty of sleep medicine, they conclude that “sleep is viewed as a basic biologic process that affects all individuals and has significant impact on the function of all organ systems.” The International Classification of Sleep Disorders is a 400- page, stand-alone document that was written in 1990 and revised in 2005.2 Sleep medicine deals with sleep and arousal disorders that include all conditions encountered clinically. It deals with dyssomnias, which are those disorders that involve initiating and maintaining sleep, as well as with parasomnias, which are movements and behaviors that occur during sleep.3 Obstructive sleep disorders are classified as dyssomnias and represent those disorders resulting from airway obstructions that occur during sleep. They are relatively common syndromes and by conservative estimates affect five percent of the Western world,4 but they are often under-recognized despite having substantial morbidity and mortality rates associated with them. Treatment for obstructive sleep disorders ranges from the extremely conservative measures of weight loss and sleep position training to variations of continuous positive airway pressure (CPAP), oral appliance therapy and surgery. Many patients prefer the concept of oral appliance therapy to either the use of CPAP or surgery.5 A dentist should then be involved with patient evaluation, insertion and appliance maintenance as well as managing post-appliance insertion complications.6 Consequently, one might think that oral appliance therapy would be a considerable portion of many dentists’ general practices. But this is not the case. The Carrot of Economic Success It isn’t unusual to see an advertisement refer to the potential economic boom that a course will provide for the participant. Silber states that 30 to 50 percent of the population older than 50 snores.7 This is often interpolated to 40 percent. So, if 40 percent of your adult population snores, and you have a practice with 2,000 active adult patients, 800 of your patients snore. If you treat only 25 percent of them, and you bundle the workup and appliance fee to a moderate charge of $3,000, then your gross income should increase by $600,000 the first year. Unfortunately, that is an unrealistic computation. The literature ignores the many challenges that face dentistry. Let’s examine some of those challenges. The Physician’s Bias The past few decades have seen the line between dentistry and medicine continually blur, as dentists have made significant contributions to the care of patients with chronic daily headache, migraine and facial pain. There was a bias among sleep physicians against early attempts at oral appliance therapy. Pantino reports that when he began treating with oral appliances it was not only considered experimental, but with limited data, research, no consideration of coverage from the insurance industry and with limited physician support, he may as well have been “practicing witchcraft.”8 The 1995 landmark study by Schmidt-Norwara9 opened the door to the need for dentistry and medicine to work synergistically and pointed out that as health-care providers, we are challenged to acknowledge the necessity for interdisciplinary communication.10 This early bias is complicated by the fact that obstructive sleep disorders are indeed a medical disorder. Obstructive disorders are a continuum of disorders that start with snoring. Therefore, snoring should not be treated without a medical diagnosis, and that diagnosis should be done by a physician.6 In spite of the tremendous improvements in oral appliance therapy, the fact that oral appliances are usually preferred by patients over the alternatives of CPAP or surgery, and the fact that the Academy of Sleep Medicine has mandated by policy that some patients not only can, but in some cases should, be treated or given oral appliance therapy, physician bias against oral appliances still exists. It isn’t enough for dentists to know just the basics of sleep medicine and oral appliances. Dr. Schmidt-Norwara wrote that “dentists who offer this service need to become acquainted with the multifactorial nature of sleep medicine to serve their patients better and to facilitate their interaction with other sleep medicine clinicians.”11 A high level of mutual respect and open communication is required for the medical and dental professions to properly triage and treat patients. In a position paper on practice parameters by Kushida, et al., it is stated that oral appliances should be delivered and followed by qualified dental personnel “who have undertaken serious training in sleep medicine and/or sleep-related breathing disorders with focused emphasis on the proper protocol for diagnosis, treatment, and follow up.”6 Challenges Beyond the Science In order to be successful in incorporating dental sleep medicine into your practice, understanding the science of sleep medicine and possessing the ability to insert oral appliances is not enough. The art of implementing the science requires a different skill set than was required to develop a general dental practice. In order to be successful, dentists must have strong communication skills. For the most part, general dentists can work within their own office walls and choose those specialists with whom they would like to work. In sleep medicine, dentists must immediately work to develop relationships of trust and mutual respect with physicians with whom they might have no past relationship and with whom they have had limited contact. Furthermore, because many physicians hold the bias discussed earlier in this paper, they will often have to be educated and motivated to refer patients for oral appliance therapy. There is also the matter of “management” and the potential for failure. The dental model of practice doesn’t usually involve “managing” disease; we treat it and cure it. Obstructive disorders can’t be “cured,” a concept I have found not readily accepted by some dentists. Dentists need to develop a new mindset and a new definition of success for the practice of dental sleep medicine. They must learn that success cannot be determined with an explorer or depend totally on the polysomnogram results. They must also realize that some patients will be unable to wear their appliances. Dentists must quell their disappointment and acknowledge that although they have rendered the best possible care, there are factors beyond their control that impact the success of oral appliance therapy. This potential for failure should not dampen their enthusiasm. Fear of failure should not prevent them from helping many other patients. Making this realization and sharing this information with the patient prior to treatment is a total change in the model that dentistry routinely utilizes. There is also the obstacle of post-insertion management. The oral appliance helps maintain the airway during sleep by creating an external splint, resulting in an increased tonic tone to the relaxing pharyngeal musculature.12 In order to do this, there is a strain placed on the muscles of mastication, as well as the temporomandibular joint itself.13 General dentists are not well trained in joint anatomy, physiology or in the treatment of joint dysfunction.14 These common complications will sometimes frustrate the dentist who might not be trained in the ability to diagnose, treat or manage these adverse effects on the joints or muscles. This frustration has the potential to cause the dentist to stop treating with oral appliances. Training in these areas of treatment is readily available, and will allow the dentist to manage these complications and make wise risk/benefit decisions concerning the continued use of the oral appliance. The most common adverse effect is occlusal changes.13 Dentistry has long emphasized the role of occlusion, and it is difficult for the dentist to make an informed risk/benefit decision if that role is considered more important than the resolution of the patient’s obstructive disorder. Ferguson states, “This presents a clinical dilemma when the patient is unconcerned about the occlusal changes and refuses to abandon the appliance citing that the perceived benefit of treatment outweighs the dentist’s concern with the altered occlusion.”13 Dental malocclusions created by oral appliance therapy might have limited or no effect on the patient’s aesthetics or function, and it might be much more beneficial for the patient to continue to wear his or her appliance despite the occlusal changes. It is counterintuitive for the dentist to do anything that creates a malocclusion, and yet this might be in the patient’s best interest. This is a difficult concept for dentistry. Why the Hidden Agenda? This is, no doubt, an exciting and new field. We are all aware of today’s economics, and the need for general dentistry to find new income potential. On the surface, an argument can be made about how successful dentists can be by adding dental sleep medicine to their regimen. It is clear that challenges exist, and that we are more likely to be successful and conquer the challenges if we are aware of them from the beginning. The rosy picture that is often painted isn’t real, and many dentists who take their initial course in dental sleep medicine are soon disenchanted by the unexpected roadblocks to success. Is the promise of economic gain, then, a conspiracy? The answer is simple. Yes, it is a conspiracy if there is some implication that implementing dental sleep medicine is as simple as finding patients in your office who snore and treating them with oral appliances that you fabricate easily with impressions and bite registrations sent to a lab. There are real challenges that face dentistry in the field of dental sleep medicine. These challenges include: Becoming a serious student of sleep medicine Educating your medical colleagues about the potential service you can provide their patients who might benefit from oral appliance therapy Understanding the need to manage your patients and understanding their role as key players on the treatment team Learning how to communicate with local sleep labs and physicians by keeping them in the loop and referring patients back to them for post-treatment evaluations Establishing reasonable fee structures and understanding the need to process claims through medical insurance in order to get the most coverage for your patients Learning more about the craniomandibular structures that you are compromising in order to support a compliant airway Carefully reconsidering some of your occlusal concepts that will prevent your potential bias from keeping patients from treatment for this serious disorder that is associated with substantial morbidity and mortality rates15 unique place in our health-care system, it has the responsibility to screen patients for OSA.16 Ninety percent of OSA remains undiagnosed.17,18 Our patient load would be well served if all dentists had a better understanding of sleep disorders. Our profession and our patients would benefit if all dentists were taught the basics of sleep medicine and consequently screened their patients. But more intensive study on many levels and a commitment to consider the model changes discussed are required before the dentist can provide oral appliance therapy and create an other income source in his or her office. The conspiracy is on the part of those who might gain economically in the short run by having dentists construct snoring appliances for those patients who snore (even if it means without proper diagnosis) or by encouraging dentists to take courses be cause of the perceived economic gain without recognizing the obstacles to that end. Furthermore, the conspiracy often encourages the front-end purchase of equipment that is not required to perform dental sleep medicine; again, in the long run, this frustrates the general dentist who is not aware of the obstacles that prevent the successful implementation of dental sleep medicine in his or her practice. Many well-done studies have now been completed to demonstrate over and over again the potential of oral appliance therapy to be successful in mild, moderate and even severe sleep apnea.13 Certainly, oral appliance therapy has been implemented into many dental practices success fully. Some dentists around the country have actually limited their practices to dental sleep medicine. The obstacles can be overcome. But before they can be overcome, they have to be recognized and acknowledged. It is essential, then, that the “conspiracy” not result in frustration and the dentist deciding not to pursue dental sleep medicine. Those who have accepted the challenges and overcome the obstacles have placed themselves in a position to provide a potentially life-altering and life-saving treatment modality. The diligent dentist has the opportunity to add not only a new stream of income for his practice, but also a new quality of life for his or her patients. References Shepard, J.W., Jr., et al., History of the development of sleep medicine in the United States. J Clin Sleep Med, 2005. 1(1): p. 61-82. American Sleep Disorders Association, D.C.S.C., ed. International Classification of Sleep Disorders: Diagnostic and Coding Manual. 2005, American Academy of Sleep Medicine: Westchester, IL. Kryger, M.H., T. Roth, and W.C. Dement, Principles and practice of sleep medicine. 4th ed. 2005, Philadelphia, PA: Elsevier/Saunders. xxxiii, 1517 p. Young, T., P.E. Peppard, and D.J. Gottlieb, Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med, 2002. 165(9): p. 1217-39. Ferguson, K.A., et al., A randomized crossover study of an oral appliance vs nasal-continuous positive airway pressure in the treatment of mild-moderate obstructive sleep apnea. Chest, 1996. 109(5): p. 1269-75. Kushida, C.A., Morgenthaler, T.I., Littner, M.R.,etal, Practice Parameters for the treatment of snoring and obstructive sleep apnea with oral appliances:an update for 2005. SLEEP, 2006. 29(2): p. 240-243. Silber, M.H., Krahn, Lois E., Morgenthaler, Tomothy I., Sleep Medicine in Clinical Practice. 2004, Boca Raton: Taylor & Francis. Pantino, D.A., Joining Forces. Sleep Review, 2008. 9(3): p. 34-5. Schmidt-Nowara, W., et al., Oral appliances for the treatment of snoring and obstructive sleep apnea: a review. Sleep,1995. 18(6): p. 501-10. Glassman, B.H., Multidiciplinary Is Not a Dirty Word. Cranio, 2004. 22(2): p. 87-89. Schmidt-Nowara, W., A review of sleep disorders. The history and diagnosis of sleep disorders related to the dentist. Dent Clin North Am, 2001. 45(4): p. 631-42. Hoekema, A., B. Stegenga, and L.G. De Bont, Efficacy and co-morbidity of oral appliances in the treatment of obstructive sleep apnea-hypopnea: a systematic review. Crit Rev Oral Biol Med, 2004. 15(3): p. 137-55. Ferguson, K.A., et al., Oral appliances for snoring and obstructive sleep apnea: a review. Sleep, 2006. 29(2): p. 244-62. Klasser, G.D. and C.S. Greene, Predoctoral teaching of temporomandibular disorders: a survey of U.S. and Canadian dental schools. J Am Dent Assoc, 2007. 138(2): p. 231-7. Eckert, D.J. and A. Malhotra, Pathophysiology of adult obstructive sleep apnea. Proc Am Thorac Soc, 2008. 5(2): p. 144-53. Barsh, L.I., The recognition and management of sleep-breathing disorders: a mandate for dentistry. Sleep Breath, 2008. Young, T., et al., Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. Sleep,1997. 20(9): p. 705-6. Baumel, M.J., G. Maislin, and A.I. Pack, Population and occupational screening for obstructive sleep apnea: are we there yet? Am J Respir Crit Care Med, 1997. 155(1): p. 9-14. Author’s Bio Barry Glassman, DMD, maintains a private practice in Allentown, Pennsylvania, which is limited to chronic pain management, head and facial pain, temporomandibular joint dysfunction and dental sleep medicine. He is a diplomate of the American Academy of Craniofacial Pain, a fellow of the International College of Craniomandibular Orthopedics, a fellow of the Academy of Dentistry International and a diplomate of the American Academy of Pain Management. He is on staff at the Lehigh Valley Hospital where he serves as a resident instructor of craniomandibular dysfunctions and sleep disorders. He is a diplomate of the Academy of Dental Sleep Medicine and is board certified in dental sleep medicine. He is on staff at the Sacred Heart Hospital Sleep Disorder Center. He was recently named Co-Medical Director of the St. Luke’s Hospital Headache Center. – See more at: http://www.dentaltown.com/dentaltown/article.aspx?i=247&aid=3242#sthash.sD3ey2uG.dpuf

Retired NFL players are very aware of sleep apnea

I met Derek Kennard early in his process. He was really suffering with fatigue and it was affecting all aspects of his life. His snoring was a real problem of course and it was affecting his relationship with his wife. His real problem was the big dark circles under his eyes and his inability to stay awake. I noticed he was exhibiting all the classic symptoms of obstructive sleep apnea syndrome. As it turned out his real battle was with the therapy. He had excellent therapists who really pulled out the stops to find the appropriate patient interface. CPAP was just not something that Derek was able to comply with. Kennard has become a very outspoken proponent of oral appliance therapy, he has worked with many clinical organizations including ours to educate patients and clinicians about OSA and all the possible treatments.-ed It is Time to Wake up to Sleep Disorders Sleep Disorders have dominated the health and wellness blogs and news sites for the last several years. It is time for patients and caregivers to wake up to the issues that come from sleep apnea. More than 40% of adults in the U.S. have a disorder such as snoring, insomnia, restless leg syndrome or sleep apnea, according to recent studies. Dr. Patricio Reyes head of Neurology Veteran’s affairs hospital Phoenix AZ says in his recent experience it’s now clear that a lack of sleep “not only increases the risk of errors and accidents, it also has adverse effects on the body and brain,”. Neurological impact of sleep according to shows a clear implication in Dementia, Parkinson’s disease and Alzheimer’s disease. Yet most sleep disorders go untreated. Derek Kennard often relates the story that until he began treatment with a sleep Herbst oral appliance he had not slept for more than 2 hours at a stretch  Derek Kennard a former NFL center and Dallas Cowboys Super Bowl champion who was tough enough to play a championship game against the Pittsburgh Steelers with a separated shoulder was almost brought down by sleep apnea. He just didn’t sleep well at night. Only grabbing sleep in 2 hour increments.  Kennard says his wife reported his breathing would stop, she would need to nudge him to get him breathing again. His passion for publicizing sleep diagnostics and therapy comes not only from his obvious success but from the fact that his brother a diagnosed sleep apnea patient passed away in his sleep from a heart attack. Heart problems are a recognized complication of sleep apnea. Reggie White also passed in his sleep of a heart attack. Kennard is very aware of the large segment of the population that have sleep apnea. In his role as a school councilor, he has seen the signs and symptoms of obstructive sleep apnea in his coworkers. So this condition is not only a condition related to the bigger guys on the team. Sleep Apnea is often associated with obesity which can create a false impression of a patient’s potential risk. Kennard’s brother was 6’4” and skinny as a rail. Once his condition was identified Kennard went to a sleep Dr for a few tests. The most important test was an overnight sleep study. As part of the study he was put on CPAP. CPAP is a device that blows air up your nose and holds your airway open. This device is considered the gold standard or best in class therapy for obstructive sleep apnea. Kennard found that this was not a treatment he could tolerate. The greatest impact Kennard’s condition had on his life was the sleepiness that came from waking every 2 hours. This sleepiness caused mood swings, concentration issues and of course drowsy driving. He reported falling asleep while driving often stopping on the way home from work for a short nap to improve his concentration. Many Studies have been done in the sleep lab at Arrowhead Hospital “A patient who is young who is young, healthy and fit can be put them in a pre-diabetic state just by putting them on an irregular sleep schedule,” Reyes, says. It is also shown in recent research that there is also a strong connection between sleep and the immune system, Reyes says. “People who do not sleep well have a 200 to 300 percent increased risk of actually catching a cold,”. Dr. Rudi Ferrate a sleep Dr. from Arrowhead Hospital says i“My whole clinic is full of patients who are brought in by their spouses,”  When a patient is being initially diagnosed assessed Dr. Ferrate uses a simple questionnaire call the Epworth sleepiness scale. This is a list of 8 simple questions which have been validated to give a very accurate prediction of sleepiness. Dr. Ferrate is a board certified sleep physician who is focused on all of the more than 94 sleep disorders from bed wetting and nightmares to sleep apnea. Sleep Apnea affects 1 in 3 adult makes in the United States. Dr. Ferrate requires an objective measure of sleep quality using an at home or in hospital sleep study in order to form a diagnosis of sleep apnea. Sleep Apnea is a term that refers to the absence of airflow either due to airway obstruction or due to neurological component in which the brain does not ask for a breath. The treatment for Sleep Apnea is continuous positive airway pressure (CPAP) device or, more recently an oral appliance like a sleep Herbst. Derek Kennard’s wife couldn’t stand his snoring, but she didn’t love listening to his CPAP machine either. Kennard was concerned that “Darth Vader machine took the sexy out of the bedroom. Kennard said to me I can’t wear thing that thing, I feel like I am drowning. “Some players have such severe sleep apnea that they must use both a CPAP machine and a Herbst device to get restful sleep, but Kennard is glad that the device is adequate for his treatment. Sleep diagnosis at home or in the sleep lab is a very important part of getting treated. This will provide an objective diagnosis for the sleep physician to evaluate your condition and suggest a treatment. There are a wide range of options for treatment. CPAP for severe cases mild to moderate cases with the sleep Herbst and in some cases positional therapies with a slumberbump body position device. This can be purchased through

Interdisciplinary cooperation is critical for Sleep Apnea Treatment

It is axiomatic in the treatment of sleep apnea that primary care physicians, dentists, therapists and sleep physicians work together for the benefit of the patient. In the article below that was previously presented by Dr Viviano in the online publication SleepScholar.com, Dr Viviano presents how the system can fail, from the point of view of an individual patient. I was really struck by the tenacity of the patient seeking treatment. He clearly understood he had a problem and was using every possible asset at his disposal to solve it. In Canada OA’s are available over the counter, Health Canada regulates this space to protect the patient. It would be interesting to me to look at the documentation provided by these devices. Was there any guidance in the IFU’s to suggest how to deal with tooth movement? How about evaluating periodontal condition? In my experience these documents tend to be relegated to “fitting guides”. Trouble shooting can also be a rudimentary affair. What if any responsibility does the manufacturer have for online or telephone clinical support? Another point that occurs to me in areas where OTC (Over The Counter) appliances are available, what if any training, education is provided to the dental community to help them support patients who come seeking care? In the case of the patient below it took 3 different dental visits to achieve what could be considered actionable information for the patient. I am very interested in any comments you might have regarding this excellent article by Dr Viviano – ed   A Cautionary Tale: For Physicians, Dentists and Regulatory Boards Recently, I saw a patient in my dental sleep clinic referred by his general Dentist. He was originally referred to a Sleep Physician that arranged an in-lab sleep study, establishing a moderate level of sleep apnea (Overall AHI = 19, Lateral AHI = 12). After demonstrating intolerance to CPAP, he visited the Sleep Physician requesting to try an oral appliance, something he read about on the Internet. The Sleep Physician flatly refused to provide him with a referral and insisted that he wear CPAP. Unfortunately, this scenario plays out all too often in North America leaving patients to their own devices. Many simply do nothing and remain untreated for many years before revisiting the notion of finding a remedy for their problem. I routinely, see patients in this situation, sometimes left untreated for up to 5 years. That wasn’t the case here. This patient went back to the Internet and when he read that the American Academy of Sleep Medicine (AASM) recommends Oral Appliances for Mild to Moderate sleep apnea, he started researching online where he could find one. One of the appliances he read about was the SnoreGuard. He didn’t have to look far to find one. In Canada, the SnoreGuard is sold over-the-counter and he simply picked one up at a local Shoppers Drug Mart. Of course, he was encouraged when the box it came in read “Approved for Mild to Moderate Sleep Apnea”. He purchased his SnoreGuard for $50 Cdn, and over the following two years purchased 7 more for a grand total of $400 Cdn. As far as effectiveness went, it reduced but did not eliminate his snoring and was completely ineffective in supine position. Of course, he had no way of knowing if it was having any impact at all on his Sleep Apnea. Near the end of this period, he noticed that his lower anterior teeth had moved, that he was experiencing increasing pain in these same teeth and that his overall bite had changed. So, he returned to the Internet looking for alternative appliances and found the MyTap. Before we move to the present and his MyTap experience, I want to discuss what else occurred during the two-year time frame that he wore the ApneaGuard. About half way through that time period, he researched online for an appliance that may better manage his snoring while sleeping supine, and discovered the SnoreRx (snorerx.com: $100 US). He ordered and fitted it himself, using the included directions. However, after one week of wear he went back to the ApneaGuard as the TMJ discomfort that he was experiencing made wearing the SnoreRx unbearable. During those two years, he attempted to get into the care of a professional to help him.  He found two Dentists that advertised that they made oral appliances to manage Sleep Apnea. The first Dentist recommended that he needed over $3000 worth of dental work before making the 3D printed nylon appliance he was being shown, (I have examined his teeth and the term “a bit over the top” is an understatement). The second Dentist conducted a full exam, radiographs etc. ($450 Cdn) and then advised him that the only way he could make him an appliance was if he agreed to a Home Sleep Test at the cost of $400 Cdn out of pocket (his in-lab sleep study was one year old at that time).  Understandably, this patient walked out of both of those offices without an appliance. By the way, at no time was the patient asked to produce a Physician’s prescription for an oral appliance. In all fairness, that request may have come further along in the process, but that remains questionable. Now, back to MyTap and the present. Disillusioned by all of the above, this patient once again resorted to his online efforts to find a solution and came across the MyTap. He called to order a MyTap appliance ($200 Cdn) from a local CPAP store that he found online. He was told “We sell a lot of them and we are all sold out presently, but we will get more later in the week. Why don’t you come in and we’ll fit it for you then”. So, the patient went in. Although the individual that fitted the appliance was very pleasant she did not appear to be very experienced. However, together, they finally got the MyTap fitted comfortably. He was provided some written and verbal instructions on both the MyTap and the AM positioner, and was sent home. Never to be seen again, unless he needed a new MyTap. Literally, one stop therapy! I inquired if anyone checked his teeth, or his TMJ, or looked in his mouth, at the CPAP store, the answer was no. When I enquired if it was a Dentist or perhaps a Denture Therapist, the answer was no. I can only assume that in between dispensing CPAP machines this individual is literally throwing in oral appliances for anyone that has $200 and will open their mouth! So there he was, on his own with the most comfortable appliance to-date, but not quite sure what to look for to determine if it was working or how far forward he should adjust it, etc. This is when he asked his general Dentist for advice and was subsequently referred to our clinic. We follow protocols recommended by the American Academy of Dental Sleep Medicine (AADSM). So, we asked this patient to provide recent radiographs from his Dentist, a copy of his original sleep study and a prescription for an oral appliance to manage sleep apnea written by his Physician. He agreed to a full consultation and oral examination including TMJ evaluation and periodontal/dental charting. I checked to see if the MyTap was fitted properly and I advised him on how to adjust it and what to watch for. In addition he was given my email so that he could contact me with questions or issues. We also discussed the tooth movement that had taken place with the SnoreGuard. He was so impressed with the time I took and the thoroughness that was exhibited that he advised me that he will have a proper custom appliance made once this trial MyTap appliance proves this approach will work for him. In an email exchange with me he wrote, “I’d also like to tell you that it was a pleasure finally meeting someone who is so passionate, astute and open minded about what you do while putting the patients needs squarely first. I finally feel like I am in good hands for treating my apnea”.  Note to all Physicians and Dentists, patients can tell when you sincerely care about them! This is a sad state of affairs; when patients can obtain and treat themselves for a life threatening disease with such ease, even having a so-called professional in a medical facility that dispenses CPAP throw an appliance in like it is a pair of earrings. Maybe, someone should just open a Kiosk at the local Mall and sell Oral Appliances and fit them on the spot. Just train an 18 year old how to heat them up and put them in the mouth, pay them minimum wage and I bet there’s money to be made! This gentleman’s story helps to exemplify much of what is wrong with how Sleep Medicine is currently practiced. Unfortunately, everyone has failed this gentleman, leaving him to his own devices. Thankfully, he pursued relentlessly his desire to mange his Sleep Apnea and I am confident that we will be able to help him manage it adequately. Clearly, there are many “cautions” that result from this gentleman’s experience. Ignoring a patient’s preference for an alternative treatment that is literature validated and supported by the current guidelines is WRONG A Primary Care Physician not following up and providing assistance in finding alternative therapy in cases of CPAP intolerance is WRONG Providing appliances without performing a proper evaluation and arranging for proper follow-up is WRONG Insisting that a patient have a Home Sleep Test that he will have to pay for out of pocket when he has a recent in-lab Sleep Study is WRONG Prioritizing elective high-end dental treatment over the management of sleep apnea is WRONG Making management of life threatening diseases available over the counter is WRONG This type of blatant disregard for a patient’s best interest is WRONG The New Guidelines jointly published by the AASM and AADSM are meant to provide clinician’s guidance based on the most current literature, to blatantly ignore them is WRONG. Unfortunately, this scenario plays out daily in every city of every region throughout North America, and that’s simply WRONG. Abandoned by Medical Professionals, this patient was left to his own devices to manage his problem without their aide and when he attempted to seek help from Dental Professionals engaged in this area of practice, we also let him down, and that’s simply WRONG. Consider this a Cautionary Tale for Physicians, Dentists and Regulatory Boards. John Viviano DDS D ABDSM SleepDisordersDentistry.com SleepDisordersDentistry Linkedin Group

Cigarette Smoke and COPD Link Confirmed

Researchers from Brown University examined healthy patients’ and smoking patients’ lung samples in order to demonstrate that the expression of the pathways in immune responses is decreased in COPD patients. The researchers examined the relationship between NLRX1, the protein known to inhibit the MAVS/ RIG-1-like helicase pathway, in the clinical stage of current and former smokers with COPD. The team found that measured levels of the protein are a sign of cigarette induced emphysema, similar to the lung destruction that is seen in patients with COPD. “This is a new school of thought in terms of what causes emphysema and a new school of thought regarding how cigarette smoke does what it does,” corresponding author and pulmonologist Jack A. Elias, MD, dean of medicine and biological sciences at Brown University, explained in a press release. “We’re showing that a lot of what’s going on is related to mitochondria.” Then, the investigators repeated a similar experiment in mice models. They were able to show a direct relationship between cigarette exposure, NLRX1, and the MAVS/ RIG-like helicase pathway. In this experiment, when the mice were exposed to smoke, they demonstrated lower levels of NLRX1 expression than the control mice which were not exposed. Mice that were biologically engineered to lack the gene for NLRX1 developed an advanced degree of emphysema when exposed to the cigarette smoke. “Our observation is that NLRX1 is a critical inhibitor of MAVS/ RIG-like helicase signaling that is affected by cigarette smoking exposure,” said study lead author Min-Jong Kang, a researcher at both Yale and Brown, continued in the statement. “We observed that the levels of this molecule could explain diverse aspects of disease severity and patient’s symptoms.” Through even more experiments, the authors of the study solidified their hypothesis that NLRX1 is connected to the MAVS/ RIG-like helicase pathway in the context of cigarette smoke exposure in both human and mice models. However, there are still unanswered questions. Specifically, the researchers have yet to determine exactly how cigarette smoke suppresses NLRX1 in human subjects. One difference the scientists noted between humans and mice models of this experiment is that once the cigarette smoke exposure ceases in mice, the inflammation tends to die down – but in human cases, it does not. “We now have a common denominator that seems to bring all these hypotheses together,” Elias concluded. He added that single nucleotide differences in the protein’s gene may change a person’s susceptibility to COPD. References: https://news.brown.edu/articles/2015/05/copd http://www.jci.org/articles/view/71747 http://www.hcplive.com/medical-news/a-near-definitive-link-between-cigarette-smoke-and-chronic-obstructive-pulmonary-disease www.mdspiro.com

Positional Apnea Therapy could make the difference

Many patients have difficulty with CPAP compliance. I have heard over the years many clinicians refer to an over reliance on CPAP therapy for obstructive sleep apnea. While CPAP fits nicely into the in lab sleep diagnostic setting, long term compliance rates tend to be low when this device is used in the home. It is a stretch in the minds of some to consider a therapy with only 50% adherence after 45 days, according to some studies, the gold standard. A major challenge in today’s medical reimbursement climate is that CPAP compliance requires skilled therapists working with the patients often over several visits to get the right mix of device, interface and behavioral modification. David Gergen offers us a look into the experience of a retired NFL player who took a different path. I like this story because it lays out how Mr Mark Walczak took ownership of his condition and perused a therapy combination that worked for him.  I have met Mr  Walczak and was very impressed with his commitment to patient advocacy around sleep issues and expect him to contribute a great deal to the sleep apnea community in the Phoenix area. – ed Mark Walczak: A Big Guy with Big Sleep Problem I have been in the sleep therapy field for over 20 years. In that time I have witnessed the effect on patients of what I can only call an over reliance on CPAP therapy in treating OSA. Many of my close friends are ex NFL players like Roy Green, Carl Eller, Derrek Kennard, Markus Allen, Eric Dickerson and Mark Walczak who have tried CPAP but found themselves unable to comply with their prescribed therapy. Pro Player Health Alliance was founded to help these icons of the NFL share their experiences and perhaps help patients find therapy that will help them maintain their health and get a good nights sleep. I am particularly struck by the story of Mark Walczak who has suffered with sleep apnea for many years. After undergoing an in lab sleep study it was shown that Mark had an AHI (Apnea Hypopnea Index) of 62. This is classified as severe sleep apnea “a big guy with a big sleep problem”. Mark was prescribed with CPAP and tried to wear it but was unable to make the therapy work for him. Studies indicate that CPAP compliance is very low and is dependent on great coaching and highly engaged medical team that work a wide range of patient interfaces and desensitization protocols. This is all in an effort to help the patient adjust to wearing a mask at night with a column of pressurized air blowing into the airway. The sound of the devices and the effort to maintain a clean and effective device, all this combines and contributes to reduced compliance rates. Mark ended up a casualty of this process as do about 50% of patients who start the process according to recent studies. As part of his journey to healthy sleep he met with Dr Roger Briggs DDS from Scottsdale AZ.  Dr Briggs made a Herbst sleep appliance for Mark. The Herbst appliance reduced Marks snoring and his sleep apnea to a moderate  level (AHI 17)  however it was not completely eradicated and with further testing it was shown that there was now a significant positional component. The decision was taken that a SlumberBump positional therapy device would be added to Marks sleep time protocol. SlumberBump is a very simple device that is worn around the chest to help position the patient on their side while sleeping. Studies indicate that positional therapy is as effective as CPAP in mild sleep apnea patients. In combination Mark Walczak wears a Herbst mouth piece and a Slumberbump to bed and his AHI as registered with a sleep study went from untreated AHI of 62 all the way down to an AHI of  1. This took some time, and there were trained dental and sleep clinicians monitoring and guiding the process. I would say that the best part of this approach is that the patient has control over how often how much and understands their condition so much better. I have to say oral appliance therapy in combination with body position therapy with a SlumberBump is a winner in my book. David Gergen About David Gergen David Gergen, CDT and President of Pro Player Health Alliance, has been a nationally respected dental lab technician for over 25 years. He received the award for “The Finest Orthodontic Technician in the Country” given by Columbus Dental in 1986. He also has been appointed Executive Director of the American Sleep and Breathing Academy Dental Division, a national interdisciplinary academy dedicated to sleep training and education with over 60,000 members. David rolled out of bed on December 4, 1982 and had his career “ah ha” moment. He knew he was going to be an orthodontic technician and he knew he was going to help people all over the country to help treat their sleep disorders in partnership with their dentists. He has worked for some of the pioneers in the orthodontic and sleep dentistry fields. He was the personal technician for the likes of Dr. Robert Ricketts, Dr. Ronald Roth, Dr. A. Paul Serrano, Dr. Clark Jones, Dr. Harold Gelb, Dr. Joseph R. Cohen, Dr. Rodney Willey, Dr. Allan Bernstein, and Dr. Thien Pham. One of his proudest achievements is receiving The National Leadership award for Arizona Small Businessman of the Year in 2004.  

Rem Flood and it’s relationship to sleep deprivation

How can you fall asleep while driving? What is REM sleep? What is Sleep Deprived? What is REM flood? How do you treat it? It’s so scary when this happens! You’re driving down the interstate at 75mph or you’re in heavy traffic. And almost without warning your heads falls down and pops back up because you just fell asleep! It’s happened to me too. Scariest part is the 1-2 seconds after you wake back up your still going 75 mph and your disoriented!!! And for some it ends tragically with an auto accident. Why does this happen? How can you go from awake to asleep in a split second? Well you were probably very tired to begin with. And you could feel yourself wanting to fall asleep. Then it happened. REM Flood! Your brain put you to sleep at the worst possible time. REM Flood comes from being sleep deprived because you’re not getting proper sleep. When we sleep we go through four stages, Stage 1, Stage 2, Stage 3, and REM. Stage 1 is the first stage of sleep. It is very light sleep. It should take you about 10-20 minutes to reach stage one when you lay down to sleep. If I said your name during this stage you would wake up. Stage 2 is the transition stage between light sleep and deep sleep. In stage 2 our heart rate and body temperature lower. It is also the stage where clench and grind our teeth the most. It is also called the anxiety stage. Sage 3 is deep sleep. This is the stage where our body “reboots” itself like a computer. In this stage our muscles, skin, and hair grows, our hormones are regulated, our blood pressure is regulated, and we get deep restful sleep. The last stage is REM sleep. This is the stage where we process data and memories in our brain. We do most of our dreaming in this stage. During sleep we cycle from stage 1 to 2 to 3 and then REM sleep over and over. You cannot skip any stages and you repeat the cycle all night. Our brain must have a certain amount of REM stage sleep. About 20% of our sleep should be REM stage. There is no pill, diet or supplement to get REM sleep. The only way to get REM sleep is to continually sleep though all four stages over and over every night. And if you do sleep through all your stages continually all night you will wake up feeling great and rested. The problem comes in when something breaks your sleep cycle. Snoring, sleep apnea, clenching/grinding, excess alcohol, and even certain anxiety drugs can cause breaks in your sleep cycle. Let’s use snoring as an example. You have just fallen asleep. You have entered stage 1. You are now drifting into stage 2. You’re just about to enter stage 3 when you start to snore. You’re losing air while you’re snoring so your brain wakes you up for a split second. You take a deep breath, roll over and fall right back asleep. But you don’t start back where you left off at stage three. When something breaks your sleep cycle you start back at stage 1. So if something is affecting your sleep all night you may not go through your sleep stages enough times. This means your brain did not get enough REM stage sleep. In other words, your sleep deprived. If you stay sleep deprived long enough your brain will eventually demand REM stage sleep. When this happens you can fall asleep no matter what you’re doing. I can remember staying awake all night in dental school studying for neurology finals. For 2-3 days I went with maybe 4 hours of sleep. My brain was starving for REM sleep. I remember coming back to my apartment after the final and I crashed on the couch. I did not even make it to my bedroom. I slept for about 10 hours! This is called REM Flood. It’s when your brain puts you straight to sleep and you cycle very quickly through stages 1, 2, and 3, and stay in REM stage longer. This allows your brain to make up for the lost REM sleep it needs. Your brain is “flooding itself” with REM sleep. For some people that work really long hours or late at night they take very short but very restful “power naps”. They are sleep deprived and make up for it with daily short naps between sleep. The problem is when REM Flood occurs but you’re not at home to sleep safely in your bed. You’re in your car driving. When this occurs the brain essentially shuts off and on very rapidly. It puts you to deep sleep for a split second and then wakes you up. Hopefully you are still on the road after this happens. The only way to ensure you are not sleep deprived is to sleep and sleep properly so you go through all your stages. For many of us that is not something we do every night. If you are having problems falling asleep, staying asleep all night, or falling asleep during the day you can be helped. For our patients we start with a home sleep study or some prefer to go to a sleep center for their study. When you come to see us to help you sleep there are two people I need to meet, the “awakeyou” and the “asleep you”. These are two different people. The “awake you”can tell me what you remember about your sleep but that’s about it. The “asleep you” can tell me everything I need to know to get you to a great night sleep every night. To accomplish this we set you up with a sleep study and from there we can help you make changes to how you sleep. If you have a snoring or sleep apnea problem we can make a dental appliance to keep your jaw forward so your tongue does not block the air from entering your lungs. It looks kind of like a sports mouth guard. You do not have to use a CPAP if you don’t want to. For some it is simply changing their diet and/or medications. Everyone has their own unique problems sleeping well. So we start with a consultation and talk about how you are sleeping. And then we make recommendations based on what we hear. Simple. Everyone can have a great night sleep every night!  

COMPLIANCE AND EFFICACY OF TITRATABLE THERMOPLASTIC VERSUS CUSTOM MANDIBULAR ADVANCEMENT DEVICES

Friedman M, Hamilton C, Samuelson CG, Kelley K, Pearson-Chauhan K, Taylor D, Taylor R, Maley A, Hirsch MA. Source Advanced Center for Specialty Care, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA. Abstract Objective. To share our experiences treating patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) with titratable thermoplastic (TPD) and custom-made mandibular advancement devices (MAD) and to compare these devices in terms of objective improvement and cure and treatment success (improvement/cure plus adherence at 6 months).Study Design. Case series with planned data collection.Setting. Tertiary care center.Subjects and Methods. Patients with OSAHS who failed or refused both continuous positive airway pressure (CPAP) and surgery had a titratable oral appliance fitted. Patients were offered an office-fitted TPD or a custom-made dentist-fitted device. Assessment included pretreatment and appliance-titration polysomnography (PSG). Improvement was defined as ≥50% apnea-hypopnea index (AHI) reduction plus posttreatment AHI <20, and cure was defined as AHI <5. Patients were contacted at 1 and 6 months regarding treatment adherence.Results. A total of 180 patients (123 TPD, 57 custom) with complete PSG data were reviewed. Improvement/cure were significantly better with the custom device overall (91.2%/71.9% vs 77.2%/52.0%, P = .024/.012). Adherence data at 1 and 6 months were obtained from 128/180 and 119/180 patients, respectively. Using an intention-to-treat analysis, those lost to follow-up were considered nonadherent. Adherence at 1/6 months was 64.9%/50.9% for custom versus 53.7%/32.5% for TPD (P = .156/.018), yielding treatment success rates (with initial improvement/cure) of 49.1%/40.4% for custom versus 27.6%/17.1% for TPD (P = .005/<.001) at 6 months.Conclusion. Custom-fit devices achieve higher rates of objective improvement and cure of OSAHS than TPD at the time of titration-PSG. TPDs have a high acceptance rate, low cost, and reasonable initial improvement and cure rates of 77.2% and 52.0%, respectively, but significantly poorer 6-month compliance. Otolaryngol Head Neck Surg. 2012 Mar 7

Bacteria may be key to non smoking compliance

A bacterial enzyme may be a future candidate in smoking cessation, according to a new study led by researchers at The Scripps Institute. Findings from the study are published in the Journal of the American Chemical Society. Current smoking cessation aids have proven to be ineffective in at least 80–90% of smokers. This novel enzyme therapy would be to eliminate nicotine before it reaches the brain as to not trigger a smoker into relapse. The NicA2 enzyme is found in the, which is originally from soil in a tobacco field. The bacteria consumes nicotine as its one source of carbon and nitrogen. Researchers set out to test its potential efficacy as a therapeutic agent. The team combined serum from mice with a nicotine dose equivalent to one cigarette. When the enzyme was added, they found the nicotine’s half-life was cut from 2–3 hours to just 9–15 minutes. A higher dose of the enzyme could decrease the half-life of nicotine even more and prevent it from reaching the brain. The team then tested the enzyme to assess its practicality as a drug candidate. The enzyme remained stable in the lab for over three weeks at 98 degrees Fahrenheit. Also, the scientists did not find any toxic metabolites produced when the enzyme broke down nicotine. Future studies will include improving the enzyme’s serum stability so that a single injection can last up to a month, researchers concluded. References: http://www.empr.com/news/why-bacteria-may-be-a-future-smoking-cessation-aid/article/431885/ Scripps.edu As Previously published on MD Spiro Blog